The infrastructure for on-site upcycling

Our pipeline enables on-site upcycling to be economical, integrate with existing operations, and deploy quickly to novel sidestreams.

End-to-end pipeline for sidestream bioprocess design

Symbio has developed a computational pipeline for the technoeconomic evaluation of upcycling systems, and the discovery of novel enzymatic processes. Click through the pipeline to read more.

Run a sidestream analysis

Perform preliminary analysis on your sidestream and see platform functionality.

Schedule a feasibility study

Use the platform for your R&D

Leverage our pipeline for your academic research or commercial R&D.

Contact us
TRL 1–2 Live

Product Discovery

Predict stream composition, high-value targets and potential outputs using proteomic and genomic modeling.

  1. Compositional fingerprinting of diverse sidestreams.
  2. Enzyme-substrate screening and strain matching
  3. Preliminary yield prediction from experimental and protein expression data.
  4. Output price and margin prediction with market grounding.
TRL 2–3 Live

Feasibility analysis

Automated TEA and LCA for preliminary assessment of system feasibility under varied configurations and operational conditions. Simulate processes and compare economics at different scales, product purities and uptime conditions.
  1. Automated process design and simulation.
  2. Preliminary TEA at pilot and commercial scales
  3. Preliminary LCA and Scope-3 emissions reduction estimates
  4. Feasibility reports with full data provenance
TRL 3–4 Beta

System designer

Design and build systems in a visual workbench built on an academically-validated simulation platform. Model upstream, fermentation and downstream processing operations with operational parameters. Simulate process scale-up with experimentally-grounded models.
  1. Unit operation selection and configuration
  2. Process flow diagram construction
  3. Mass and energy balance simulation
  4. Scale-up parameter modeling
TRL 4–5 Beta

Technoeconomic analysis

Perform automated technoeconomic analysis with built-in uncertainty modeling and comprehensive empirical grounding. Assess economics under uncertainty with market and process-side price modeling with market grounding.
  1. Capital and operating cost estimation
  2. Revenue and margin modeling
  3. Market-grounded price sensitivity analysis
  4. Uncertainty quantification and scenario modeling
TRL 5–6 In progress

Lifecycle analysis

Simulate and analyze environmental impacts including global warming potential, resource consumption and toxicity. Predict wastewater and discharge midpoint metrics and negative carbon credits from avoided emissions.
  1. System boundary and functional unit definition
  2. Inventory analysis across upstream inputs
  3. Midpoint environmental impact characterization
  4. Negative emissions credit quantification
TRL 6–7 Q3 2026

Regulatory assistance

Develop regulatory reports, prepare FDA GRAS notifications and track compliance. Research and assemble regulatory filings and track compliance against regulations and voluntary certification schemes.
  1. Regulatory pathway identification
  2. GRAS notification preparation
  3. Compliance gap assessment
  4. Filing assembly and submission support
TRL 7–9 Q4 2026

Monitoring & optimization

Monitor and control deployed systems remotely, with alerts for key process parameters and system interruptions. View reports of system operations with realtime production data.
  1. Real-time sensor data ingestion
  2. Process KPI dashboard and alerting
  3. Anomaly detection and fault diagnosis
  4. Remote parameter adjustment

Turnkey on-site processing systems

Modular biorefineries deployed on-site in food processing facilities, built for the challenges of sidestream feedstocks. Autonomous process control, proprietary reactor designs, soft sensing and remote diagnostics ensure consistent uptime and minimal overhead.

  1. Site assessment & feedstock process design
  2. Modular skid fabrication and facility integration
  3. Automated fermentation control & continuous monitoring

System design

Dynamic sensing

Dynamic sensing systems and on-board computation allow systems to adapt to variable feedstocks and maintain consistent outputs.

Upstream stabilization

Rapid biomass reduction and stabilization allows high-throughput processing for seasonal sidestreams. Flexible upstream processing allows customization for diverse products from solid hemicellulosic to viscous liquids.

On-site Integration

Eliminate hauling and logistics costs, utilize perishable product and reduce reliance on external vendors through on-site processing. Our units are designed to integrate into existing process operations with minimal disruption and operator overhead.

Modular unit operations

Modular design enables configuration of the core fermentation process to diverse sidestreams through variable upstream and downstream operations.

Precision enzyme production

High-performance Aspergillus strains secreting tailored enzyme cocktails from your sidestream substrates. Both non-GMO and synthetically-optimized strain options available for food, feed, and industrial applications.

  1. Enzyme profile design matched to target application
  2. Solid-state or submerged fermentation pathway selection
  3. Downstream purification, concentration & stabilization
  4. QC validation to food-grade, feed, or industrial specification